There is only one file type that uses the .VPX extension:
Avast Virus Update File

- Developer Avast Software
-
Popularity
- Category Data Files
- Format Binary
Data file used by Avast, an antivirus and Internet security application; may contain virus definitions and software update information; used for keeping the software up-to-date with the latest protection signatures.
Avast typically downloads VPX files on a periodic basis to keep the software updated.
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Updated: May 20, 2020